Therapeutic Role of Antimicrobial Peptides in Diabetes Mellitus

Antimicrobial peptides (AMPs) have recently become widely publicized because they the potential to function in alternative therapies as “natural” antibiotics, with their main advantage being a broad spectrum of activity. The for antimicrobial treat diabetes mellitus (DM) has been reported. In type I (T1D), cathelicidin-related peptide (CRAMP), cathelicidin (CAMP) and mouse-β- defensin 14 (mBD14) are positively affected. Decreased levels LL-37 human neutrophil 1-3 (HNP1-3) reported II (T2D) relative healthy patients. Moreover, AMPs from amphibians social wasps antidiabetic effects. infections occurring patients tuberculosis-diabetes or diabetic foot, granulysin, HNP1, HNP2, HNP3, beta-defensin 2 (HBD2), cathelicidins responsible pathogen clearance. An interesting is also use modified M13 bacteriophages containing encapsulated genes phagemids.